The absence of expression of TLR4 on tumor cells excluded a direct cytotoxic effect of Lipo-MP-LPS as confirmed by the absence of caspase-3 mediated cell death in organotypic model of OsA treated by Lipo-MP-LPS (Supplementary Figure S2; Lipo treated OsA: 205 Cleaved Caps 3+ Cells/FOV, Lipo-MP-LPS treated OsA: 189 Cleaved Caps 3+ Cells/FOV). Here, CASP3 is linked to neoplasm.