ACHE and cancer: This is relevant because the overactivation of the PI3k/Akt pathway is a frequent event in human cancers [103,104]; therefore, we could hypothesize that the hyperactivation of PI3k/Akt could decrease AChE content; this event affects the apoptosome formation and enzymatic activity, allowing high ACh levels that promote cell proliferation and inhibition of apoptosis through ACh receptors (AChRs) (Figure 10).