EBP and central nervous system cancer: First, analysis of mRNA-seq data from The Cancer Genome Atlas (TCGA) [75] via the Gliovis data portal [76] revealed that, distinctively, from genes encoding other enzymes in the cholesterol biosynthesis pathway, EBP displayed an upregulated expression in GBMs in comparison to non-tumor tissues, as well as to lower grade gliomas (grade II and III) (Figure S5B).