EBP and central nervous system cancer: First, although EBP inhibition likely contributed to the suppressive effects of clemastine, we cannot rule out the potential promiscuity of clemastine and that additional pathways (e.g., histamine/muscarinic receptor signaling) might participate in mediating clemastine’s effects, as suggested by the remaining sensitivity of shEbp mouse glioma cells to clemastine (Figure 4E and Figure S7F).