Normally, 8-OHdG expression is regulated by hydrolysis or the cleavage of incorrectly bonded nucleotides by OGG1 [26]; impaired OGG1 activity damages DNA and cannot cleave guanosine, thus protecting the integrity of 8-OHdG, resulting in cancer development and a poor patient prognosis [39]. The gene discussed is OGG1; the disease is cancer.