While NCI-H295 and JIL-2266 were derived from primary ACC prior to systemic treatment, CU-ACC1 and CU-ACC2 originated from chemonaive ACC metastasis, while TVBF-7 and MUC-1 were derived from local and distant ACC metastasis after administration of multi-chemotherapeutic therapies. This evidence concerns the gene MUC1 and adrenal cortex carcinoma.