MTBP and osteosarcoma: The first observation of the migratory- and metastasis-suppressive role of MTBP was made using heterozygous Mtbp knockout mice in which tumors from Mtbp+/−p53+/− mice showed a higher frequency of metastasis of osteosarcoma and HCC (~20%) when compared with tumors from p53+/− mice (~3%) [10].