You et al. [13] identified Insulin-like Growth Factor 1 Receptor (IGF1R), Laminin Subunit Gamma 2 (LAMC2), Integrin Subunit Beta 1 (ITGB1) and Interleukin-6 (IL6) as “key” molecules associated with poor survival in HNSCC patients receiving radiotherapy, and Kim et al. [14] found that specific radio resistance signatures could predict outcome following radiation in HPV negative HNSCC, but that tumour subtype needed to be taken into consideration. This evidence concerns the gene IGF1R and head and neck squamous cell carcinoma.