A large number of pathways (n = 95) were also found to be enriched in down-regulated genes following 96 h of incubation on the perfusion device; in addition to the AGE-RAGE signaling pathway and the PI3K-Akt pathway discussed earlier, the top most significantly enriched pathways include those involved in the HPV infection pathway and the pathways in cancer. This evidence concerns the gene RENBP and cancer.