This is similar to a previous report whose results state that direct knockdown of β-catenin in other colon cancer cells resulted in either a slight increase or no change in the mRNA levels of CCND1 and MYC, depending on the cell types [46], suggesting that the regulation of mRNA expression by β-catenin is complicated depending on the cellular context. The gene discussed is CCND1; the disease is colonic neoplasm.