If additional, Notch-pathway-related genes such as AJUBA, EP300, and FBXW7 are included (each mutated with a frequency of 7–8% in HNSCC) and it appears that about two-thirds or >60% of all HNSCC harbor changes in Notch signaling [83]. The gene discussed is FBXW7; the disease is head and neck squamous cell carcinoma.