In addition to these results, Xu et al. recently demonstrated by applying the bioinformatic analysis that PTEN-induced putative kinase 1 (PINK1)-mediated mitophagy is inhibited in NASH mouse liver with fibrosis via the axis of upstream circular RNA 608 (circ608)-microRNA 222 (miR222)-PINK1 (circ608 inhibiting miR222) through mTOR and Wnt pathways [151]. This evidence concerns the gene MTOR and metabolic dysfunction-associated steatohepatitis.