From these data, we conclude that along with IR and activation of TGF-β, the dysregulation of Wnt/β-catenin, NRIP1, Nrf2, SREBP-LXRα, PHBs, PPARs, and p53 play an important role in NASH pathogenesis. Here, NRIP1 is linked to metabolic dysfunction-associated steatohepatitis.