NFE2L2 and metabolic dysfunction-associated steatotic liver disease: Furthermore, the mechanisms underlying HFD-induced NAFLD in mice and its upregulation were related to the alleviation of the lipid peroxidation and ferroptosis and suppression of autophagosome biogenesis through AMPK- and AKT-mediated mTOR activation, decreasing ATG7, Nrf2, and stabilizing KEAP1 [98].