Very recently Chen et al. have shown that Ufm1-specific ligase 1 (Ufl1) and Ufm1-binding protein 1 (Ufbp1), which are putative targets of ubiquitin-fold modifier 1 (Ufm1), prevent liver fibrosis, subsequent steatohepatitis, and HCC development in diethylnitrosamine DEN-treated mice by inhibiting the mTOR pathway [138]. The gene discussed is UFL1; the disease is hepatocellular carcinoma.