CNPY2 has also been identified as playing a crucial role in ER stress and UPR-related diseases, including metabolic disorders, NAFLD, inflammation, and cancer, by regulating the PERK-C/EBP homologous protein (CHOP) pathway [47,87] (Table 1 and Table 2). This evidence concerns the gene DDIT3 and metabolic dysfunction-associated steatotic liver disease.