In a study from 2003, Zwaan et al. showed a CR rate of 70% and 5-year OS, EFS and DFS of 32%, 29% and 41%, respectively, in a group of 27 children with FLT-ITD treated between 1990 and 2001 within an AML-BFM study group and DCLSG. This evidence concerns the gene FLT1 and acute myeloid leukemia.