Furthermore, CXCR2 ligands, particularly PF-4 and CXCL10, in combination with hematopoietic cytokines such as c-kit ligand, granulocyte colony-stimulating factor (G-CSF), granulocyte–macrophage colony-stimulating factor (GM-CSF), and interleukin-3 (IL-3), may reduce the proliferation of AML cells [87,88]. This evidence concerns the gene CXCR2 and acute myeloid leukemia.