A survival inconsistency in PD-L1 overexpressing NSCLC (higher than 50%) was previously reported by Zens and Colleagues but Kaplan–Meier results become significant when adopting the cut-off of 1% (p = 0.03), regardless histology (SqC 47.4%/ADCs 52.6%) [19]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.