This result is relevant since MM tumors are infiltrated by mast cells where they contribute to angiogenesis and MM growth [45,46], but in the presence of a tumor-specific IgE these mast cells would degranulate resulting in an acute inflammatory immune response as well as the release of pro-apoptotic compounds and stimulators of the immune response [29,47,48,49], which may potentially result in antitumor activity. Here, IGHE is linked to neoplasm.