AQP1 and colonic neoplasm: The AQP1 ion channel blockers used in this study were AqB011 [11,20,28,64], previously shown to inhibit migration and invasion in AQP1-expressing colon cancers [11,12], and the furan compounds 5-HMF and 5-PMFC, shown to block the AQP1 cation conductance in red blood cells at 0.5 to 1 mM, as well as to reduce colon cancer motility at similar concentrations [29,30].