TP53 and cancer: Many STMN1-inducible upstream factors, such as E2F [22], mutant p53 [23,24], PTEN loss [25], NF-κB [26], Sonic hedgehog signal [27], PPP1R14B [28], and diverse microRNAs [24,29,30,31,32], have been reported to promote aggressiveness in several cancers.