We used different GBM cell lines, i.e., IDH1wt and MGMT hypermethylated U87MG human cells [40,41,42,43,44], IDH1wt and low MGMT methylated U118MG human cells [43,45,46], IDH1wt and unmethylated MGMT U138MG human cells [43,44], and IDH1wt and MGMT hypermethylated GL261 mouse cells recapitulating human GBM features [16,47,48,49,50]. This evidence concerns the gene MGMT and glioblastoma.