RAF1 and thyroid tumor: This could be beneficial for a subgroup of PTC patients, because vemurafenib and dabrafenib have been shown to not only inhibit the RAF/MEK/ERK pathway in thyroid tumors, but also to induce redifferentiation and radioactive iodide restoration [15,16,19,52,53] via re-expression of the sodium/iodide symporter (NIS) [54].