Statistical analysis of the basal profiles yielded five peptides (ADDB_696-708, ERF_519-531, GSUB_61-73, LMNB1_16-28, and PP2AB_297-309) that showed a significantly different signal (p < 0.05, FDR 76%) and was able to differentiate BRAF V600E from non-BRAF V600E thyroid cancers (Figure 4A). Here, BRAF is linked to thyroid cancer.