Therefore, even though the 7-minute-long half-life of tTF-NGR makes its SPECT-based biodistribution analysis challenging, [108] Persigehl et al. demonstrated the feasibility of SPECT in the verification of the selective tumor-homing potential of the fusion protein and in the quantitative assessment of tTF-NGR uptake in U87-glioblastoma-xenografted CD-1 nude mice. Here, RHOH is linked to neoplasm.