The synergistic effect of the NGR tripeptide for tumor-homing was proved by fluorescence imaging, which revealed meaningful accumulation of the DOTA/Alexa647-HA100-N compound with the NGR motif in NCI-H292- and A549-lung-tumor-carrying BALB/c mice, while, on the contrary, the NGR lacking agent did not accumulate in either of the tumors (DOTA/Alexa647-HA100). This evidence concerns the gene RTN4R and neoplasm.