APN/CD13 is massively overexpressed in several cancers; examples include but are not limited to breast, prostate, ovarian, thyroid, pancreatic, colorectal, non-small-cell lung cancer and malignant pleural mesothelioma [51,52,53,54,55,56,57,58]. The gene discussed is ANPEP; the disease is malignant pleural mesothelioma.