IDH1 and central nervous system cancer: Using a CRLB <40% for the detection of 2HG, 9/12 (75%) cases were correctly identified as IDH-mutant or IDH-wild-type gliomas by SVS and 10/12 (83%) by 1H-MRSI (Figure 4 and Figure 5, respectively), with an overall concordance rate of 79% (19/24).