CD40LG and diffuse large B-cell lymphoma: In DLBCL, only the IgM PP has been reported, by almost all authors from the western world, to be a strong prognostic factor, independent from the IPI score, for both PFS and OS [33,34,35,36,38] Noteworthy, Cox et al., reported the detection of recurrent mutations in high impact genes, and the preferential IGVH4-34 gene usage, which allowed them to hypothesize that most IgMs-DLBCL originate from immune-escaped autoreactive B-cells [36].