One-hundred-and-one (32%) subjects had paraproteinemia (EMZL = 50%, NMZL = 28%, SMZL = 22%), the predominant type was IgM (56%), followed by IgG (31%) and IgA (3%); biclonal PP and light chain PP was found in 5% each. The gene discussed is CD40LG; the disease is Paraproteinemia.