CD274 and neoplasm: A systematic review and meta-analysis of 17 phase III randomized clinical trials involving 11,166 patients with gastroesophageal cancer revealed that the most significant predictors of improved overall survival benefit from ICI were microsatellite instability and tissue-based PD-L1 expression (tumor proportion score/TPS for squamous and combined positive score/CPS for adenocarcinoma) [130,131].