Interestingly, sites of active MV release serve as convergence points of multiple intracellular trafficking pathways, of which many components are subsequently loaded in tumor MVs, such as the Ras-related GTPases RhoA, Rab22a, and Rab35, and the ADP-ribosylation factor 6 (ARF6) [73]. The gene discussed is ARF6; the disease is neoplasm.