These tau deposits are associated with increased granular expression of active tau kinases p38-P Thr180/Tyr182 and SAPK/JNK-P Thr138/Thr185, thus suggesting that abnormal tau hyper-phosphorylation depends, at least in part, on the activation of specific kinases, as seen in human tauopathies [33,34]. This evidence concerns the gene MAPK8 and tauopathy.