CCN2 and cyst: Although the experimental samples analyzed herein do not allow us to state conclusively that YAP expression and transcriptional activity has a causal effect on COD pathogenesis, the potential functions exerted by CTGF, BIRC5 and ANKRD1 (YAP-TEAD-target genes that were increased in cystic GCs herein) may represent strong evidence of its potential key role in cyst formation and persistence.