Analysis of germline variants present in 12 known DLBCL-associated genes (MYC, BCL2, BCL6, EZH2, GNA13, PTEN, TP53, TNFAIP3, PRDM1, CD79B, CARD11, and MYD88) [5,6,7,16,17,18,19] and their PPI networks annotated via string DB revealed several stereotypic moderate- to high-impact variants (Figure 7). This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.