According to the previous experimental results, we want to know whether the neuroprotective function of CSS in the nematode model of PD is the same as in the SH-SY5Y cell model by enhancing the activity of parkin (the orthologue in C. elegans is pdr-1) to promote expression of TFAM (ortholog in C. elegans is F45E4.9) and NRF1 (ortholog in C. elegans is SKN-1A). Here, POU2F3 is linked to Parkinson disease.