Elevated MAT2A levels were observed in various types of cancer, including CRC, hepatocellular carcinoma (HCC), and breast and endometrial cancers, and are mostly considered as an unfavorable prognostic marker (https://www.proteinatlas.org/ENSG00000168906-MAT2A/pathology, accessed on 17 July 2023) [53]. This evidence concerns the gene MAT2A and colorectal carcinoma.