GRIN2B and Alzheimer disease: Importantly, we previously observed a decrease in Src activation/phosphorylation in the hippocampus of 3-month-old 3xTg-AD male mice but enhanced Src activation in the hippocampus of 15-month-old 3xTg-AD female mice, both occurring concomitantly with similar changes in phosphorylation of the GluN2B subunit at Tyr1472 [23].