Interestingly, we previously showed a decrease in Src phosphorylation/activation in the hippocampus and cortex of a 3-month-old 3xTg-AD mouse male, while an increase in Src phosphorylation was observed in the hippocampus of a 15-month-old 3xTg-AD mouse female [23], suggesting a dynamic regulation of this SFK. The gene discussed is SRC; the disease is Alzheimer disease.