MAPK8 and myocardial infarction: In 2016, an evaluation of intravenous lycopene use in surgically induced myocardial infarction was conducted, finding that lycopene supplementation by intravenous injection significantly reduced myocardial infarction during in vivo reperfusion in rodents as well as significantly inhibited fatty acid oxidation and the activation of JNK signaling during reperfusion [161].