Interestingly, Marden [69] showed that female ALS mice, lacking a copy of the X-chromosomal Nox1 or Nox2 genes, exhibited significantly increased survival rates, thus suggesting that a 50% reduction in NOX1/NOX2 expression levels might be associated with a substantial improvement of ALS outcome in mice. The gene discussed is CYBB; the disease is amyotrophic lateral sclerosis.