In this context, the recent correlation of increasing SOD1 intracellular levels in T cells with the presence of circulating Tregs in a cohort of subjects affected by Multiple Sclerosis undergoing effective immune-modulating treatment [24], strongly supports the idea that a SOD1-mTOR regulatory network [93,94] may participate in the complex mechanisms regulating immune-modulation processes. The gene discussed is SOD1; the disease is multiple sclerosis.