The aqueous extract from Codium fragile decreased nitrite production, protein expression of iNOS, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, and ADAMTS-5 against IL-1β-induced osteoarthritis with the regulation of the MAPK/NF-κB signal [13]. This evidence concerns the gene ADAMTS4 and osteoarthritis.