In this respect, Han et al. reported that, in MG-63 cells, IL-1β secreted by polarized M2 tumor-associated macrophages (M2-TAMs) induced the expression of several OS metastasis markers via the NF-κB/miR-181α-5p/RASSF1A/Wnt pathway [71]. Here, RASSF1 is linked to neoplasm.