Our results document that the genetic deletion of Nrf2 in db/db mice was associated with attenuated DKD features (SBP, FBG, GFR, urinary ACR, tubular lipid accumulation, kidney injury) in tandem with decreased expression of AGT, SGLT2, and CD36 protein and mRNA in RPTCs. This evidence concerns the gene NFE2L2 and diabetic kidney disease.