NFKB1 and obesity due to melanocortin 4 receptor deficiency: In a murine model of obesity-associated asthma, NAC treatment decreased malondialdehyde (MDA) and elevated GSH and suppressed NF-κB activation as demonstrated by a decline in inhibitor κB kinase (IKK)-β and NF-κB-P65 and elevation in inhibitor (I)κB-α [142].