However, a post hoc exploratory analysis of the subjects enrolled in the PANTHER-IPF clinical trial determining specific polymorphisms in the toll-interacting protein (TOLLIP) and MUC5B genes showed that NAC improved the prognosis in genetically predisposed individuals carrying the rs3750920 (TOLLIP) TT genotype [78]. Here, TOLLIP is linked to idiopathic pulmonary fibrosis.