DUOX1 and familial pancreatic carcinoma: To determine if the differential expression of DUOX contributes to morbidity or mortality in PDAC, the Cancer Genome Atlas (TCGA) Pancreatic Cancer Database (PAAD) was utilized to evaluate the correlation between DUOX1 methylation status (as determined by Illumina Human Methylation 450 BeadChip) and overall survival [35].