P-AscH− and AZD combine to increase DUOX1 expression and decrease tumor growth in vivo—To determine the effects of P-AscH− and AZD in vivo, separate groups of mice with established MIA PaCa-2 tumor xenografts were divided into four groups and treated for 3 weeks with NaCl (controls, 4 g/kg 1 mol/L daily), P-AscH− (4 g/kg daily), AZD (1 g/kg, three times weekly), or a combination of P-AscH− and AZD. Here, DUOX1 is linked to neoplasm.