Another example is given by the thioredoxin system (Trx), including NADPH, thioredoxin, and thioredoxin reductase, which plays a key role in redox homeostasis in all living cells, yet Trx-1 is overexpressed in many cancers and in DLBCL, conferring an advantage to lymphoma cells [152,153,154]. This evidence concerns the gene TXN and diffuse large B-cell lymphoma.