ATP7B and Wilson disease: In a cohort of 103 patients from Germany with early-onset PD (aged 41 ± 6.8 years), a single patient was identified who had an ATP7B allele with a mutated exon 14, which resulted in a change to H1096Q in the nucleotide-binding domain (this mutation is detected in almost half of all Caucasian WD patients) [136].