CP and Wilson disease: Conversely, copper deficiency in the Golgi complex of hepatocytes causes a decrease in holo-Cp levels, the copper/protein ratio in Cp, and the total copper content in blood serum (<20 mg Cp/100 mL and ~500 μg of copper/L in WD patients, versus about 35–38 mg of Cp/100 mL and ~1000 μg of copper/L in healthy individuals).