Later, the analyses of the lesional transcriptome of acute and chronic Ccm3 mouse preclinical models showed that adaptive immune response pathways, such as chemotaxis and activation of neutrophils and leukocytes, chemokine production, and cytokine secretion, were only enriched in the chronic model with more mature lesions akin to symptomatic human CCMs [52]. Here, PDCD10 is linked to cerebrocostomandibular syndrome.