In the cross-sectional comparisons of patient groups with healthy controls, most of the studies consistently reported elevated S100B levels in both drug-naïve/drug-free or SCH-medicated patients [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35], but also no differences [34,37,38], or lower S100B, in SCH compared to HC [39,40] were reported. Here, S100B is linked to spindle cell hemangioma.