Liu et al. also suggested that early brain RT with EGFR-TKIs may improve intracranial disease control compared with TKIs alone in EGFR-mutant NSCLC with BMs, and the addition of brain RT to EGFR-TKIs as initial therapy did not appear to improve survival in unselected patients, but in patients with low DS-GPA scores 0–2 [25]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.