EGFR and non-small cell lung carcinoma: A retrospective study by Manguson et al. investigated the impact of deferring radiotherapy in patients with EGFR-mutant NSCLC with BMs and showed that the use of upfront EGFR-TKIs, and the deferral of SRS or WBRT, may result in an inferior OS and a higher intracranial progression rate [26].