Milk fat globule-epidermal growth factor 8 (MFG-E8), also known as lactadherin, widely participates in the phagocytic clearance of apoptotic cells, inhibition of inflammation, and reversal of cellular oxidative stress, and is also involved in several tumors such as melanoma, breast cancer, and colorectal cancer [159,160,161,162,163]. Here, MFGE8 is linked to melanoma.