It has been shown that chemerin participates in tissue inflammation, glucose homeostasis, atherosclerosis of the arteries, diabetic kidney disease (DKD), the progression of various nausea tumors, mediating the formation of blood vessels, and stimulating vascular smooth muscle cell (VSMC) proliferation as well as carotid intimal hyperplasia [61,62]. Here, RARRES2 is linked to atherosclerosis.