M2 TAMs secrete a variety of inflammatory factors and chemokines—such as TGF-β, IL-10, VEGF, MMP, CCL15, CCL17, and CCL22—to stimulate angiogenesis, maintain tumor cell stemness, facilitate immune infiltration, remodel tissue, and induce drug resistance, thus promoting M2 polarization [10,48,181]. This evidence concerns the gene IL10 and neoplasm.