STAT3 and central nervous system cancer: They also reported that MFG-E8 binding with its receptor integrin β3 (ITGB3) in an autocrine or paracrine manner mediates the activation of STAT3 to promote the polarization of M2 TAMs, thereby secreting factors such as TGF-β, VEGF, IL-10, ARG-1, MGL2, and CD206 to promote glioma progression (Figure 3).