Chitinase-3-like protein-1 (CHI3L1), known as human homolog YKL-40, belonging to the glycoside hydrolase family, is highly expressed in various tumors, especially in GBM, and is involved in extracellular tissue remodeling, Th1/Th2 inflammation, oxidative injury, apoptosis, pyroptosis, angiogenesis, and parenchymal scarring [153,154,155]. The gene discussed is CHI3L1; the disease is glioblastoma.