Zhang et al. showed that M2 macrophages enhance 3-phosphoinositide-dependent protein kinase 1 (PDPK1)-mediated phosphoglycerate kinase 1 (PGK1) threonine (T) 243 phosphorylation in tumor cells via the secretion of IL-6, which facilitates a PGK1-catalyzed reaction toward glycolysis by altering substrate affinity. This evidence concerns the gene PGK1 and neoplasm.