Meanwhile, in the human hepatic carcinoma cell line, G1 treatment led to a concentration-dependent elevation in LDL receptor expression, and the effects of G1 were attenuated by G15 as a GPER antagonist or GPER shRNA [181], suggesting that GPER plays an important role in regulating LDL receptor expression and LDL metabolism. The gene discussed is GPER1; the disease is hepatocellular carcinoma.