AKT1 and atherosclerosis: In a rabbit model of atherosclerosis induced by a high-fat diet and compression balloon, GPER reduced arterial lipid levels including total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides (TG), and increased high-density lipoprotein (HDL) through inhibiting endothelial apoptosis and endothelial dysfunction via the PI3K/Akt pathway [192].