In addition, GPER has also been reported to inhibit inflammation [85,86,87], tumor cell migration, and tumor angiogenesis through reducing phosphorylation, nuclear localization, and the transcriptional activity of NF-κB, and TNF-α- or lipopolysaccharide-induced IL-6 secretion [88,89,90,91]. This evidence concerns the gene NFKB1 and neoplasm.