In a pathological model of atherosclerosis in female mice, a loss of GPER increased total cholesterol (TC) and low-density lipoprotein (LDL) levels [32], and treatment with G-1 was effective in attenuating atherosclerosis in postmenopausal mice, which was associated with a significant reduction in vascular inflammation [32]. This evidence concerns the gene GPER1 and atherosclerosis.