NFKB1 and Hyperglycemia: The high-glucose-induced hyperacetylation of p65 and the inhibition of HDACs (histone deacetylases) have been reported to be stimulated by the CBP/p300, resulting in NF-κB activation and the further increased transcription of IL-6 and TNF-α in monocytes [108].The above-mentioned study by Yun et al. revealed curcumin’s ability to decrease monocyte hyperglycaemia-induced cytokine production, probably via epigenetic changes in NF-κB, proving the direct action of curcumin on the inflammatory response.