Gonzalez et al. [109] reported the decreased monocyte CD33 expression and increased TNF-α production by human monocytes under hyperglycaemic conditions, thus making CD33—a member of the family of sialic acid-binding, immunoglobulin-like lectins—a subject of many studies related to the hyperglycaemia-induced inflammatory response. The gene discussed is TNF; the disease is Hyperglycemia.