A study investigating the glucose-lowering effect of Salsalate (a pro-drug of salicylate) demonstrated its effectiveness in lowering the HbA1c and fasting glucose levels of T2DM individuals [99].There is a growing body of evidence showing that low-grade chronic inflammation is one of the multiple factors underlying the pathophysiology of insulin resistance, DM, and its complications; furthermore, it is also clear that these processes might affect the insulin signalling transduction and beta cell function [61,100]. Here, INS is linked to Insulin resistance.