Finally, the analysis of microarray data revealed unique expression patterns of several genes (WTIP, TGIF, SMAD4, PPP1CB, and BMPR1A) and proteins (FOXA1, ESR1, HNF1B, BRD4, GATA4, EP300, CBX3, PRDM9, PPARG) that are influenced by circPSEN1s in the brains of individuals with AD. This evidence concerns the gene BRD4 and Alzheimer disease.