We are aware that voluntary exercise may not be feasible for some CDD patients; however, since it has been shown that involuntary or forced exercise, similarly to voluntary exercise, can improve cognitive impairment as well as induce BDNF expression [98], our findings provide support for the idea that a properly designed physical exercise program could be a valuable adjuvant to a future pharmacotherapy for CDD. The gene discussed is BDNF; the disease is craniodiaphyseal dysplasia.