Among the pro-inflammatory cytokines, TNFα is upstream of 17 of the 32 CSF delirium-associated proteins (Supplementary Figure S3A), IFNγ has a potential connection to 15/32 CSF proteins (Supplementary Figure S3B), IL-6 is upstream of 10/32 proteins (Supplementary Figure S3C), and IL-10 (Supplementary Figure S3D) is upstream of 8/32 proteins. Here, TNF is linked to delirium.