A study by Lin et al. [64] analyzing the effect of SPTBN1 in HCC cell lines and liver tissue on expression of pro-inflammatory cytokines concluded that the loss of SPTBN1 in a hepatocellular carcinoma cell line enhanced the expression of IL-1a, IL-1b, and IL-6, and it further activates the NF-κB pathway. This evidence concerns the gene IL1A and hepatocellular carcinoma.