A study by Milner et al. [48] identified gain-of-function mutations of STAT3 in whole-exome sequencing data of patients with childhood-onset autoimmunity and lymphoproliferative disease without a genetic cause, hypothesizing that mutations in STAT3 cause altered regulatory T cells and cytokine signaling, causing the immunomic reaction. This evidence concerns the gene STAT3 and Autoimmunity.