HDAC2 and cardiac hypertrophy: In a study conducted by Patel et al., the selective inhibition of HDAC2 using sodium butyrate in a rat model of cardiac hypertrophy induced by partial abdominal aorta constriction (PAAC) resulted in a reduction in collagen levels between myocardial cells and an enhancement in mitochondrial DNA concentration, although the underlying pathway was not proposed [92].