Alcohol- or HCV-induced cirrhosis has been shown to have elevated levels of leuko-endothelial (CD31+/41−), lymphocyte (CD4+), pan-leukocyte (CD11a+), erythrocyte (CD235a+), and cytokeratin-18 (CK18) positive micro-vesicles [165]. The gene discussed is KRT18; the disease is Cirrhosis.