Oncoguard LiverTM uses an algorithm based on sex, age, and alpha-fetoprotein (AFP) along with methylated homeobox A1 (HOXA1), empty spiracle homeobox 1 (EMX1), and TSPY-like 5 (TSPYL5) to improve early detection of HCC [156,157]. The gene discussed is TSPYL5; the disease is hepatocellular carcinoma.