Their study showed that for HCC patients with AFP < 10 ng/mL, the Doylestown did not improve the detection rate of HCC (AUROC of 0.6417 for the Doylestown algorithm and 0.6313 for the AFP alone) compared to those with high AFP (10–100,000 ng/mL), where AUROC was 0.579 for AFP alone and 0.700 for the Doylestown algorithm. This evidence concerns the gene AFP and hepatocellular carcinoma.